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Wednesday, February 1, 2012
Gene mutation in autism found to cause hyperconnectivity in brain's hearing center
Gene mutation in autism found to cause hyperconnectivity in brain's hearing center: "These effects could be blocked, however, by chemically negating the effect of PTEN loss. One of the pathways regulated by the PTEN protein involves shutting down an intracellular enzyme called mTORC1, which promotes cell growth, among other things. Zador's group found that treating the PTEN-deficient mice for 10 days with the mTORC1-inhibitor rapamycin prevented an increase in dendritic spine number and signal strength."
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