Join CafeMom Today! Autism Spectrum Disorder: Treatments: December 2011

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Wednesday, December 21, 2011

Mitochondrial Dysfunction and Autism Spectrum Disorders: A Simplified Approach by Daniel Rossignol, MD, & Richard Frye, MD, PhD

Mitochondrial Dysfunction and Autism Spectrum Disorders: A Simplified Approach by Daniel Rossignol, MD, & R...

Tuesday, December 13, 2011

Buspar for Autism? (buspirone hydrochloride,Vanspar)

Autism Therapy: Buspar (buspirone hydrochloride) | Healing Thresholds

Autism Therapy: Buspar (buspirone hydrochloride)
definition of Buspar (buspirone hydrochloride): Buspar® is indicated for the management of anxiety disorders or for short-term relief of more severe symptoms of anxiety. Buspirone may be prescribed off-label for people with autism to help reduce anxiety and aggression and to help improve behaviors. Buspirone has helped improve behaviors in some people with autism. This medication is currently being tested in children and adults with autism.

Friday, December 9, 2011

Response Interruption/Redirection (RIR)

Response Interruption/Redirection |

OVERVIEW: Response interruption/redirection (RIR) is an evidence-based practice used to decrease interfering behaviors, predominantly those that are repetitive, stereotypical, and/or self-injurious. RIR often is implemented after a functional behavior assessment (FBA) has been conducted to identify the function of the interfering behavior. RIR is particularly useful with persistent interfering behaviors that occur in the absence of other people, in a number of different settings, and during a variety of tasks. These behaviors often are not maintained by attention or escape. Instead, they are more likely maintained by sensory reinforcement and are often resistant to intervention attempts. RIR is particularly effective with sensory-maintained behaviors because teachers/practitioners interrupt learners from engaging in interfering behaviors and redirect them to more appropriate, alternative behaviors.

Thursday, December 8, 2011

Gaming treatment for autism

Gaming treatment for autism used in Issaquah - KAYU

One in every 110 kids in the United States have autism, but the Lakeside Center for Autism in Issaquah is turning technology into treatment.

"It`s always a barrier for our kids with autism to connect socially and with peers especially," said Lakeside counselor Peiera Miller.

That's where the Kinect comes in. The gaming system is helping to teach basic skills most of us take for granted.

When Landon Kacatin arrived at Lakeside three years ago, he wasn't talking. "He's OK with adults, but with children that's very difficult for him; he would avoid it all the time," said his mother, Laconia Kacatin.

After just a year of playing games on the Kinect, Landon isn't just talking to other kids, he's rooting for them.

More @,0,6183377.story

CM-AT Trial Targeting Core Symptoms of Autism

Autism Jabberwocky: First Drug Targeting Core Symptoms of Autism Nears?

Curemark LLC Reports Positive Phase III Results of CM-AT In Children With Autism
Wednesday, December 7th - 2011

RYE, New York, Dec. 7, 2011 – Curemark LLC, a Rye, New York-based drug research and development company, today announced that its Phase III double blind randomized placebo controlled multicenter clinical trial of CM-AT for autism met its primary and secondary endpoints. The trial compared CM-AT to placebo in children with autism aged 3 – 8. Top line results demonstrate a statistically significant effect of CM-AT over placebo on both core and non-core symptoms of autism. Analysis of the full trial data is ongoing and the results will be presented at an upcoming medical meeting.

“We are extremely pleased with the results of our trial,” said Dr. Joan Fallon, CEO of Curemark. “We wish to thank all the children and their parents who participated in the study, and look forward to a full review of the data by the FDA.”

CM-AT has been granted Fast Track status by the Food and Drug Administration (FDA). The fast track programs of the Food and Drug Administration are designed to facilitate the development and expedite the review of new drugs that are intended to treat serious or life-threatening conditions and that demonstrate the potential to address unmet medical needs.

Wednesday, December 7, 2011

Acupuncture for Autism?

Acupuncture for Treatment of Autism Spectrum Disorders


Background. There has been lack of reviews of evidence on efficacy, methodology, and/or safety of acupuncture in autism spectrum disorders. This paper examines the emerging evidence of the effects of acupuncture in the treatment of autistic children. Method. A literature review was completed via Medline and three Chinese search engines. A total of 31 studies were evaluated for acupuncture methodology, study design, treatment effects, and tolerability. Results. The acupoints used, the duration of needling, the frequency of treatment, the choice of stimulation, and the course of the treatment were highly variable amongst the studies. Behavioral and/or developmental improvements were reported in all acupuncture treatment studies. All studies reported general tolerability. Weakness of experimental designs was discussed. Conclusions. Vigorously controlled double-blinded clinical trials are needed to evaluate the efficacy and safety of acupuncture in children with autism spectrum disorders.

ScienceDirect - Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease : Mast cell activation and autism

ScienceDirect - Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease : Mast cell activation and autism

Research Highlights

►Allergic problems are common in autistic individuals. ►Perinatal mast cell activation may contribute to brain inflammation. ►The peptide neurotensin is increased in serum of autistic individuals.

Ecstasy (MDMA) Autism Treatment?

Can Ecstasy Treat Autism? | Drugs | AlterNet

A team of scientists at a California non-profit organization just announced a pilot study to determine if Ecstasy might help fight the effects of autism. This isn’t the first time that MAPS, or the Multidisciplinary Association for Psychedelic Studies, has researched the psychiatric benefits of MDMA. A 2010 study of twenty Iraq veterans suffering from Post-Traumatic Stress Disorder found that a combination of Ecstasy and therapy resulted in an 80-percent success rate, high enough to convince the Food and Drug Administration to greenlight further studies of the drug.

Lexapro for Pervasive Developmental Disorders

An open-label trial of es... [J Am Acad Child Adolesc Psychiatry. 2005] - PubMed - NCBI

To assess the effect of escitalopram in the treatment of pervasive developmental disorders (PDDs).

This 10-week study had a forced titration, open-label design. Twenty-eight subjects (mean age 125.1 +/- 33.5 months) with a PDD received escitalopram at a dose that increased weekly to a maximum dose of 20 mg as tolerated. The Aberrant Behavior Checklist-Community Version (ABC-CV) and the Clinical Global Impression scale (CGI) were used to assess outcome.

Lexapro for Autism?

A pharmacogenetic study of escitalopram in autism... [Autism Res. 2010] - PubMed - NCBI

To determine the effect of serotonin transporter polymorphism promoter region (5-HTTPLR) genotypic variation (low, intermediate, and high expression groups) on response to escitalopram treatment of children and adolescents with autism spectrum disorders (ASDs).

Monday, December 5, 2011

‘Sensitive Santa’ Meets Kids With Autism - ABC News

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‘Sensitive Santa’ Meets Kids With Autism - ABC News

A trip to the mall to sit on Santa’s knee is a special event for families, but the holiday hustle and bustle can be overwhelming for kids with autism. That’s why Northtown Mall in Blaine, Minn., opened its doors early Sunday morning for some low-key “sensitive Santa” time.
“A lot of children with autism aren’t able to have the experience of seeing Santa,” said Northtown’s marketing director Linda Sell, describing the typical bright lights, loud music and long line. “This is our way of helping.”
The mall dimmed the lights and lowered the music volume to make autistic children more comfortable. And instead of waiting in line, kids colored or walked around with their families.
“It’s something very small on our end but it means so much to families, ” said Sell.
An illustrated pamphlet showed families what to expect during their visit — a helpful aid for kids with autism who often rely on routines. And a form filled out by parents in advance gave Sensitive Santa the scoop on their wish lists.
“Its’ such a wonderful event,” said Sell. “It’s heartwarming to see the joy in the kids’ faces, and in the parents.”
The U.S. Centers for Disease Control and Prevention estimates that one in 10 children is on the autism spectrum.
The event is emotional for parents, some of whom thought they’d never see their kids on Santa’s knee.
“You have things you look forward to with your child,” mom Gena Elverhoytold ABC News affiliate KSTP with a shaky voice. “It’s different, this way, to be able to still have these experiences that you want to have.”

Afinitor for Autism?

Autism May Involve Disordered White Matter in The Brain | Medindia

BOSTON,Dec. 5, 2011/PRNewswire-USNewswire/ -- It's still unclear what's different in the brains of people withautismspectrum disorders (ASDs), but evidence from genetic and cell studies points to abnormalities in how brain cells (neurons) connect to each other. A study at Children's HospitalBostonnow provides visual evidence associating autism with a disorganized structure of brain connections, as well as defects in myelin -- the fatty, insulating coating that helps nerve fibers conduct signals and that makes up the brain's white matter.

Researchers led byMustafa Sahin, MD, PhD, of the Department of Neurology,Simon Warfield, PhD, director of the Computational Radiology Laboratory, and first authorJurriaan Peters, MD, of both departments atChildren's, used advanced magnetic resonance imaging (MRI) to image the brains of 40 patients (infants to age 25) with tuberous sclerosis complex and 29 age-matched,healthycontrols. Tuberous sclerosis is a rare genetic condition often associated with cognitive and behavioral deficits, including ASDs about 50 percent of the time.


Armed with thesedata, Sahin has launched a Phase II clinical trial of a rapamycin-like drug called Afinitor® (everolimus; formerly RAD001), sponsored byNovartis, the Tuberous Sclerosis Alliance and Autism Speaks. The trial will enroll 50 patients with TSC to test whether Afinitor improves neurocognition, autism, seizures and sleep disorders. "Specifically modulating neurocognition with a small molecule is only starting to be done," says Sahin. (For more on this trend, seethis related blog post.)

Read more:Autism May Involve Disordered White Matter in The Brain | Medindia

Face Recognition Research May Aid Therapies For Prosopagnosia And Autism

Face Recognition Research May Aid Therapies For Prosopagnosia And Autism

"Face recognition is an important social skill, but not all of us are equally good at it," says Beijing Normal University cognitive psychologist Jia Liu. But what accounts for the difference? A new study by Liu and colleagues Ruosi Wang, Jingguang Li, Huizhen Fang, and Moqian Tian provides the first experimental evidence that the inequality of abilities is rooted in the unique way in which the mind perceives faces. "Individuals who process faces more holistically" - that is, as an integrated whole - "are better at face recognition," says Liu. The findings will appear in an upcoming issue of Psychological Science, a journal published by the Association for Psychological Science

Friday, December 2, 2011

Prozac for Autism?

Prozac May Lessen Autism Symptom in Adults

Dec. 2, 2011 -- The antidepressant Prozac appears to be useful for treating a defining symptom of autism spectrum disorder -- repetitive, compulsive behavior.

In a newly published study involving autistic adults, half of those who took Prozac (fluoxetine) experienced meaningful declines in repetitive behaviors.

More @

Thursday, December 1, 2011

Trained Peers Better at Aiding Autistic Kids with Social Skills

Trained Peers Better at Aiding Autistic Kids with Social Skills | Psych Central News

A new study suggests training peers can help children with autism spectrum disorder improve their social skills, even more than a direct adult-led intervention.

Researchers led by Connie Kasari, Ph.D., discovered children with ASD who attend regular education classes are more likely to improve their social skills if their typically developing peers are taught how to interact with them.

Notably, the indirect educational method appears to improve skills better than if the ASD children are directly taught such skills. The National Institutes of Health-funded study suggests a shift away from more commonly used interventions that focus on training children with ASD directly may provide greater social benefits for children with ASD.

The study was published online ahead of print in the Journal of Child Psychology and Psychiatry.

More @


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