Transcranial Magnetic Stimulation (TMS) and Autism

Transcranial Magnetic Stimulation (TMS) May Alleviate Symptoms of Autism

Researcher Says He Has "Found the Pathology of Autism"

Dr. Manuel Casanova holds an endowed chair at the University of Kentucky. He's written dozens of peer-reviewed papers, and receives funding from the National Institutes of Health. Dr. Casanova is conducting research on the autistic brain -- and, according to him: "I think we have found the pathology of autism. ...It explains so much, it all makes sense."

Not only does Dr. Casanova believe he has found the pathology of autism, but he is also working on a treatment which may have the ability to lessen autistic symptoms of hypersensitivity without compromising the creativity and savant abilities that make autistic people so extraordinary.

Minicolumns in the Autistic Brain: Good News and Bad News

The outer part of the brain is called the neocortex. Within the neocortex are groups of cells called minicolumns. These minicolumns are the smallest unit of cells capable of processing information. Ordinarily, minicolumns include relatively large cells, called neurons, which allow communication not only within an individual minicolumn but also among different parts of the brain.

Minicolumns in people with autism are smaller and more numerous than normal. In addition, neurons within each minicolumn are reduced in size. This may be both good and bad, says Casanova: "Since the efficiency of connections among neurons is a function of cell size, the presence of smaller neurons in the brains of autistic patients has a dramatic effect on the way that different parts of the brain interact with each other. Brain activities that require longer projections (e.g., language) may be impaired while those that depend on shorter connections (e.g., mathematical manipulations) may be preserved or reinforced."

In other words, people with autism are exceptionally good at anything that can be processed in one area of the brain -- such as math and visual discrimination. They are, however, exceptionally bad at anything that requires coordination among various parts of the brain -- such as social skills, language and face discrimination.

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Related:

• MRI LINKS AND OTHER COOL THINGS: Autism and extraordinary ability
• Autism treatment study using aba and tms
• Look Me In The Eye: Brain Plasticity and TMS
• Clinical Trials Show Promise for Transcranial Magnetic Stimulation
• Initial Studies of Transcranial Magnetic Stimulation (TMS)
• Brain Stimulant: Transcranial Magnetic Stimulation for Autism
• Repetitive Transcranial Magnetic Stimulation (rTMS) « Hacking autism

Autism Epigenetics

Related:

• Epigenetics defines at Wikipedia - In biology, the term epigenetics refers to changes in phenotype (appearance) or gene expression caused by mechanisms other than changes in the underlying DNA sequence, hence the name epi- (Greek: over; above) -genetics. These changes may remain through cell divisions for the remainder of the cell's life and may also last for multiple generations. However, there is no change in the underlying DNA sequence of the organism;^[1] instead, non-genetic factors cause the organism's genes to behave (or "express themselves") differently.
• Can Epigenetics explain autism's causes?
• New Theory Of Autism Suggests Symptoms Or Disorder May Be Reversible
• Epigenetics of autism spectrum disorders.
• BioNews - Epigenetic link to autism
• Autism, fever, epigenetics and the locus coeruleus.

Risk, Risky, Riskier ... or Not

Autism Recovery Revisited: Tell the Chicago Tribune They Are Wrong

The Chicago Tribune is running another series of articles stating that "risky" treatments are of little use to children/people with autism (HERE). (Meanwhile, the American Academy of Pediatrics, in their backyard, will tell parents to use powerful psychiatric drugs with little to know knowledge of how they work or their long term effects on kids. Talk about risky.) We'll be sharing more info with you about the interview process these journalists followed and what did and did not make their final article. In the meantime, we invite you to send Patrician Callahan (pcallahan@tribune.com), Trine Tsouderos (ttsouderos@tribune.com) and Editor Gerould Kern (gkern@tribune.com) a polite email sharing how treatments have improved your child's life. When you send your email, include a copy in our comments, please.

We beg to differ with the slant the Tribune is taking. Children can make tremendous progress and we will share stories with you from our recovery category. Start with this little girl, who is using speech for the first time. If you ever figure out why people with autism are NOT supposed to see improvement or, God forbid, recover, let us know. The anger, skepticism and outright denial of medical care for autism is stunning.

[FULL ARTICLE: Autism Recovery Revisited: Tell the Chicago Tribune They Are Wrong]

Abilify (Aripiprazole) for Autism?

Aripiprazole (Abilify, Abilify Discmelt) is an atypical antipsychotic and antidepressant used in the treatment of schizophrenia, bipolar disorder, and clinical depression. It was approved by the Food and Drug Administration (FDA) for schizophrenia on November 15, 2002, for acute manic and mixed episodes associated with bipolar disorder on October 1, 2004, and as an adjunct for major depressive disorder on November 20, 2007.^[Wikipedia]

FDA OKs Abilify for autism-linked irritability

The U.S. Food and Drug Administration has approved top-selling Abilify as a treatment for autism-related irritability in children from the ages of 6 to 17, drug maker Bristol-Myers Squibb Co. said Friday.

Bristol-Myers and Otsuka Pharmaceutical Co., based in Tokyo, are collaborators on the development and distribution of Abilify in the U.S. and Europe.

Abilify is Bristol-Myers' second-biggest revenue generator, with $2.2 billion in 2008 sales.

The FDA's latest approval allows the drug to be used to treat symptoms associated with autism such as aggression toward others, deliberate infliction of self-injury, tempter tantrums and moodiness.

The companies said in a statement that it was intended to be used as part of a more comprehensive treatment program that includes educational, psychological and social aspects.

[FULL ARTICLE]

Opposing View: Risky alternative therapies have little basis in science -- chicagotribune.com

Autism treatments: Risky alternative therapies have little basis in science -- chicagotribune.com

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Respen-A as Autism Treatment?

Study: Respen-A medication appears to normalize brain function in autistic children

A new treatment for autism appears to normalize brain function, according to Nashville physician Fred S. Starr, MD, FAACAP, BCIA-EEG.

In addition to high serotonin levels, autistic children have a characteristically common "u" EEG pattern reflecting impaired brain function, particularly in areas of the brain responsible for social interaction, communication, speech and bonding.

However, Quantitative EEG's conducted by Dr. Starr on autistic children after three weeks on the medication Respen-A showed that the children's brain patterning changed to "normal" patterning. Starr says that behavioral improvement was also "evident". "Speech, interaction and social skills improved markedly in patients using Respen-A, and displays of frustration and anger markedly diminished," Starr said.

The theory behind the use of Respen-A was developed by private researcher Elaine DeLack, Stanwood, WA. Unlike theories that center on negative reaction to vaccinations, DeLack looked at exposure to a commonly used drug used during delivery, and at brain enzymes that affect the brain both at birth, and again as the child enters childhood.

DeLack's hypothesis (which can be viewed in slide show format at www.Neuro-Med.net) connects autism to the use of epidurals during childbirth. Epidurals were introduced into this country in the 1960's. By the mid-80's, 22 percent of women received an epidural during delivery. In the mid-90's, the number grew to 67%. Today, nearly 90% of women receive an epidural during pregnancy.

However, DeLack contends that it may not be the epidural procedure, but the drugs given in conjunction with the procedure, particularly the drug Pitocin, that has contributed to increasing numbers in autism.

Pitocin crosses the placenta to the infant's system during childbirth. The drug requires adequate production of an enzyme found in the liver (CYP 3A4) in order to rid it from the body. If the infant has a genetic inadequacy of the CYP 3A4 enzyme (found more often to be lacking statistically in boys than girls), the drug's intensity could become elevated in the infant's system, and build with another naturally occurring neurotransmitter that plays a key role in brain development: the hormone Oxytocin.

Oxytocin builds naturally in the brain during the first 7 - 10 days of life, ensuring that nerve patterning develops as it should in the brain. Once Oxytocin levels reach a naturally predetermined level, the development of the brain's nerve system (HNS system) ceases.

DeLack theorizes that the addition of Pitocin into the bloodstream of infants without adequate CYP 3A4 genetic enzymes, causes brain development to "shut off" early, stunting crucial neuro-development.

DeLack hypothesizes that a second enzyme may explain why autism shows up in many children around the age of three. The enzyme MAO-A is essential in regulating serotonin levels in the brain. In the first years of life, MAO-A levels remain high, assisting brain function. The impact of MAO-A may, in fact, cover symptoms of brain impairment in infants and toddlers.

MAO-A levels diminish as the child ages - allowing serotonin levels to rise, impacting the areas of the brain associated with communication, speech, emotion and bonding. Respen-A curbs the level of serotonin in the autistic brain.

"We see promise in all of this," DeLack says. "Further study will determine if simple modification during childbirth could be all that is needed to stem the surging tide of autism," states DeLack. And for those who have autism? "Respen-A could give them a quality of life that they - and their parents - deserve."

SOURCE Neuro-Med.net

Applied Affectionate Behavior Analysis (AABA)

Great resource for dads, How To Connect With An Autistic Child.

For fathers coming home from work and find it impossible to connect with their autistic child, it can typically be the straw that breaks the family's back. Now an autism expert and parent shares tips of how to develop affection in autistic children.

Where most children will greet Daddy with a hug or a smile, many autistic children aren’t capable of the normal affectionate interactions that keep a family intact. As Dad walks in, his son is busy lining up his toys or engrossed in the spinning wheels of an overturned toy truck. Dad calls his name over and over in hopes of those bright eyes and wide mouth to come running to him with open arms, but to no avail. He even gets down on his knees in a desperate attempt for some eye contact, but his son turns away and even pushes off his father's touch with disturbing grunts.

Emerson B. Donnell III lived that experience every day, decided to do something about it, and his research and experience has delivered results that no one could ever have thought possible. Specific strategies designed to elicit proper emotion have blossomed back into true affection. Today, Donnell’s son will greet him at the door with hugs, kisses and an engaging smile. The strategies to bring their world together has also helped his son's speech increase exponentially.

Donnell, author of Dads And Autism, Learn How To Stay In The Game from Altruist Publishing (www.dadsandautism.com) said that without the proper tools, developing a loving connection can be a monumental if not seemingly impossible task. But getting that toe hold is the seed towards healing not only the child, but the family as a whole.

“One of the greatest disappointments about children with autism is their inability to connect with other people,” Donnell said. “This is especially heartbreaking for the parent child relationship. Parents yearn to reach their child who is right in front of them, yet they have no idea how to go about it. Parents confronted with autism experience grief and loneliness at their inability to connect with their child and it can tear a marriage apart at frightening speed. As a matter of fact it's probably the greatest contributing factor to why dads leave and the widely accepted 80% divorce rate.”

Donnell’s approach combines strategies and tactics from a variety of proven sources, meshed with his own personal experiences. The result is a systematic program that enables fathers (and mothers) to bond and develop affection in their autistic child with specific tactics and strategies that can be exercised in the comfort of their homes.

“The new therapy that I’ve applied is called Applied Affectionate Behavior Analysis (AABA),” he said. “I have also coined the term Discrete Affectionate Trials (DATs). These are specific exercises designed to elicit and develop proper emotion and affection in autistic children.”

[More]

Related:

• Dad's and Autism site
• Books About Autism : Autism: Heartfelt Thoughts From Fathers (Paperback)
• Is Autism Toughest on Dads? Your Opinion Requested
• The Dad's Corner - The Autism Life.Com
• Dictionary For Dads - Fathers Autism Guide
• Autism Blog: Concluding the Series on Creative Dads

Chewing Gum as a Treatment for Rumination in a Child with Autism

Center for Autism and Related Disorders' Research Study Finds Chewing Gum an Effective Treatment for Children with Autism

According to new research conducted by the Center for Autism and Related Disorders, Inc. (CARD), the “Chewing Gum as a Treatment for Rumination in a Child with Autism” study reveals the challenging behavior of rumination can be treated effectively by using chewing gum as a replacement behavior. The study is published in the current issue of the Journal of Applied Behavior Analysis.

Rumination involves regurgitation of previously ingested food, re-chewing the food, and re-swallowing it. The study examined a child with autism who displayed chronic rumination for approximately one year, resulting in the decay and subsequent removal of several teeth. After several treatments failed, including thickened liquids and starch satiation, the child was taught to chew gum. His rumination decreased significantly when gum was made available.

[FULL ARTICLE]

Related:

• “Chewing Gum as a Treatment for Rumination in a Child with Autism” study is published in the summer 2009 Edition of the Journal of Applied Behavior Analysis, pages 381-385.

Methyl-B12 Lolipops

Absorbing vitamin MB12 in your body is not easy. Until now.

Developed by a father who recovered from symptoms of ADHD and Irritable Bowel and whose child recovered from autism, ReVitaPop offers a simple, convenient and easy way to effectively replenish your body with methylcobalamin (MB12). MB12 is the only neurologically active version of vitamin B12. MB12 is a very unique vitamin and deficiency can affect vision, intestinal function, the ability to protect against infections and toxins, nerve functioning, and DNA replication. This lollipop administration and its unique blend of ingredients are designed to provide a unique oral absorption. Most multivitamin pills do not contain M'B12 and oral absorption is often problematic.

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