Interventions: In the process of working with a neurologist, dietician, and your primary care provider, you ultimately are trying to control seizure breakthroughs in your child. Below are some common interventions I find helpful in my clinic.
Magnesium: can be dosed 10mg/kg or 10mg per 2 pounds of body weight. Any higher doses may need to have periodic blood tests to measure the blood level of magnesium.
Vitamin B6, in the form of P-5-P: we usually start at 50mg daily and depending on the age of the child, I can increase the dose up to 200mg per day.
Omega 3 fatty acids: There is some weak evidence that omega 3 fatty acids also increase the seizure threshold. Though the mechanism is unknown, we do know that omega 3 fatty acids are anti-inflammatory. There is at least some evidence that anti-inflammation may be important in raising the seizure threshold.
Ibuprofen: this is an anti-inflammatory as well as an anti-pyretic (keeps the fever down). It is especially useful in the beginning and during an illness since increases in body temperature and elevated temperatures in general can lower seizure thresholds in some children.
Hyperbaric Oxygen Therapy (HBOT): Children with traumatic brain injury or with a condition of the brain that seems to favor low levels of blood flow, demonstrated with a SPECT Scan or PET scan, may benefit from HBOT treatments. The rationale is that brain cells that receive too little oxygen (hypoxic tissue) may be more unstable and thus, may have a lower seizure threshold. By increasing the oxygen delivery to these hypoxic areas, the stabilization of these brain cells may increase the seizure threshold.
IVIG: IVIG could act on epilepsy by its broad immunomodulatory mechanism of action.
L-Carnosine: some studies have suggested that this supplement can have anti-epileptic properties.
Vitamin E: Researchers in Canada, in a very small study, demonstrated that seizures can be decreased with Vitamin E, in the form of d-alpha-tocopherol acetate. 3 year olds and older can easily tolerate 400IU per day.
Rilutek (Riluzole): can be used for anxiety and obsessive/compulsive disease and may be effective in decreasing seizures, especially when combined with some of the seizure medications.More @ http://mendingautism.com/articles/lets-talk-about-seizures/
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