Join CafeMom Today! Autism Spectrum Disorder: Treatments: Baclofen, STX209 and Autism

BabelFish Universal Language Translator

Wednesday, December 1, 2010

Baclofen, STX209 and Autism








Baclofen, STX209 and Autism

One night in 2006, Kathy Roberts rushed her autistic daughter, Jenny, to the hospital. Nothing had been able to stop the young woman, then in her mid-20s, from vomiting. Jenny had recently suffered several major seizures and her entire gastrointestinal system was going haywire.

To try to calm Jenny's GI tract, doctors at Massachusetts General Hospital prescribed baclofen, an antispasmodic drug that is also being studied as a potential treatment for alcoholism and other addictions. The drug relieved Jenny's vomiting, but it did something else too — a completely unexpected and welcome side effect.

"Within 24 hours, I saw a change," says Roberts. "Right away, I saw that it was globally calming. I've always described a state that she would get into where it seemed like she wasn't comfortable in her own skin, and was trying to crawl out. I saw that calmed down."

Roberts, founder of the Giant Step school for children with autism in Southport, Conn., called Mark Bear, professor of neuroscience at MIT and advisory board member of Giant Step. In 2005, Bear had co-founded a drug company called Seaside Therapeutics to develop treatments for autism and other developmental disorders. Roberts told Bear about baclofen's effect on her daughter, and a new line of research was born.

In September, Seaside announced positive results from a phase II clinical trial of STX209, an experimental drug that is chemically related to baclofen. In the trial, which was not blinded or placebo controlled, STX209 led to a reduction in agitation and related emotional outbursts in autistic people. Such behavior is common in people with autism — often, a result of anxiety caused by extreme sensory oversensitivity or frustration over being unable to communicate their needs. To cope, autistic people often develop behavioral mechanisms, include tantrums, social withdrawal or repetitive behaviors like rocking or hand flapping.

STX209, while not a cure, appeared to ease anxiety. "We're seeing reductions in a lot of types of outbursts and irritable behavior, along with increased communication and social behavior," says Dr. Randall Carpenter, co-founder, president and CEO of Seaside.


Read more: http://healthland.time.com/2010/12/01/how-a-new-version-of-an-old-drug-may-someday-help-treat-autism-and-addiction-too/#ixzz16tSJxkbc

Kaspersky Anti-Virus 2011


2 comments:

Jennifer said...

Such promising news! I am very interested to see where more research takes us. My daughter has sensory processing disorder but isn't considered on the spectrum due to full language capabilities, etc. I can relate to the feeling uncomfortable in their own skin comment for sure. At it's core, Autism is a brain disorder. I've been reading what Brain Balance - http://brainbalancecenters.com - has to say about the issue, that the brain can be changed and improved with the right interventions. Their site is certainly worth a read. Wouldn't it be great if one day their interventions could be used in conjunction with the right medication?

Jennifer said...

Such promising news! I am very interested to see where more research takes us. My daughter has sensory processing disorder but isn't considered on the spectrum due to full language capabilities, etc. I can relate to the feeling uncomfortable in their own skin comment for sure. At it's core, Autism is a brain disorder. I've been reading what Brain Balance - http://brainbalancecenters.com - has to say about the issue, that the brain can be changed and improved with the right interventions. Their site is certainly worth a read. Wouldn't it be great if one day their interventions could be used in conjunction with the right medication?

Labels

420 (1) AABA (1) AAT (9) ABA (27) Abilify (2) Acamprosate (1) Acupuncture (2) Adeli Suit Therapy (1) AEIOU Early Intervention (1) Afinitor (1) AIT (3) Algae (1) Alzheimer's Drugs (2) Amantadine (1) Amino Acids (1) AMMT (1) Anat Baniel Method (1) Animal Assisted Therapy (15) Anti psychotics (2) Anti-convulsants (2) Anti-fungal therapy (1) Anti-yeast therapy (2) Antibiotics (1) Antidepressants (7) Antioxidants (1) Antipsychotics (2) Applied Affectionate Behavior Analysis (1) Applied Behavioral Analysis (26) Arbaclofen (1) Art Therapy (9) Assistive Technology (18) Athletics (1) Audio-Visual Entrainment (1) Auditory Integration Training (3) Auditory Motor Mapping Training (1) Augmentative Communication (17) Autism (7) Autism Clinical Trials Network (1) Autism Fun (2) Autism Treatments are Expensive (11) Autism360 (1) AVE (1) Baclofen (2) Bacteroides (1) BCAAs (1) BDNF (1) benzodiazepine (1) Better Diagnosis (1) Biofeedback (9) Biomedical Treatments (4) Brain Plasticity (1) Branched Chain Amino Acids (1) Bumetanide (1) Bumex (1) Burinex (1) Buspar (1) Buspirone Hydrochloride (1) Cannabis (7) Cerebral Folate Deficiency (1) Character Therapy (1) Cheerleading (1) Chelation (4) Chewing Gum (1) Chiropractic (1) Cholesterol (1) CLM (1) clonazepam (1) Coffee (1) Communication Devices (16) Competent Learner Model (1) Computers (12) Contrarian (1) Cord Blood (1) Costs of Treatment (17) CranioSacral Therapy (1) Cutting-Edge Therapies (2) Cybertherapy (1) D-Cycloserine (1) DAN (5) Dance (1) DATS (2) DCS (1) DEFEAT AUTISM NOW (6) Detecting Autism (1) Detox (1) Developmental Individual Difference Relationship Model (3) Diagnosing Autism (1) Diet (6) DIR (5) Disco (1) Discrete Affectionate Trials (1) Discrete Trial Training (4) DNA (1) Dolphin Dome (1) Dolphin Therapy (8) Drugs (34) DTT (5) DynaVox (14) Early Intensive Behavioural Intervention (1) ECLIPSE Model (1) Ecstasy (MDMA) (1) EEG Biofeedback (7) EIBI (1) Elephant therapy (1) Enzyme (1) Epigenetics (3) Epilepsy (5) Epsom Salts (2) Equine Therapy (10) Face Recognition (1) Facial Reflexology (1) Fatty Acids (2) Fish Oil (2) Floor Time (8) Floortime (7) Fluoxetine (1) fMRI (1) Folic Acid (2) Functional Magnetic Resonance Imaging (1) Games (3) Gene Therapy (4) Genome Sequencing (1) Glutathione (1) Grace (1) HBOT (16) Hippotherapy (7) Hormones (1) Horse Therapy (11) Hydration (1) Hyperbaric Oxygen (16) Hyperinsulinemia (1) Hypnosis (1) Hypnotherapy (1) iCommunicate (1) Immunotherapy (1) Insurance Coverage for Autism (20) Intravenous immunoglobulin (1) iontoporation (1) iPad (9) iPhone (7) iPod (9) iPrompts (1) IVIG (1) Law of Attraction (1) LEGOS (2) Leucovorin (1) Leupeptin (1) Lexapro (escitalopram) (2) Life Skills (3) Lovass (1) Lupron (5) Marinol (1) Masgutova method (1) Masgutova Neuro-sensory-motor Reflex Integration (2) Massage (1) MB12 (4) Medical Marijuana (6) Medications (9) Meditation (1) Mendability (1) Methyl-B12 (4) Methylcobalamin (2) Miracle Mineral Supplement (2) Misc (5) Mitochondrial Dysfunction (1) MMS (2) MnemeTherapy™ (1) MNRI (1) Music Therapy (6) N-Acetylcysteine (1) NAC (1) NAET (1) Namenda (1) Nasal Insulin (1) nasal spray (2) NATURAL ENVIRONMENT TRAINING (2) Natural Language Paradigm (1) Naturalistic Learning (2) NET (1) Netbook (1) Neurofeedback (9) Neuroliminal Training (2) NHE6 protein (1) Nicotine Patch (1) Nintendo (1) NLP (1) NT (2) Nutritional therapy (1) Occupational Therapy (1) Omega-3 (3) Online Autism Therapy (3) Optimize Strengthen Rejuvenate (3) OSR (4) Oxidative Stress Release (3) Oxytocin (2) P.L.A.Y. Project (1) Parasitic Worms (1) PECS (8) PEMF (1) Physical Therapy (1) Picture Exchange Communication System (8) Pilates (1) Pivotal Response Therapy (2) Play and Language for Autistic Youngsters (1) Pot (1) Probiotics (3) Proloquo2Go (1) Propranolol (1) Protease Inhibitor (1) Prozac (2) PRT (1) Pulsed Electromagnetic Field Therapy (1) Rapamycin (1) Rapid Prompting Method (1) Reducing Oxidative Stress (1) Respen-A (2) Response Interruption/Redirection (1) RIR (1) Risperdal (1) Risperidone (4) Ritalin (1) Robots (3) RPM (1) rTMS (1) SAVE (1) Scams (1) SCERTS (1) Screening for Autism (1) Secretin (1) Seizures (4) Sensori-motor Auditory Visual Education (1) Sensory Enrichment Therapy (1) Sensory Integration Therapy (5) Service Dogs (5) Shank3 Protein (1) Shaping and Chaining (1) Sign Language (1) Single Nucleotide Polymorphisms (1) SIT (1) Skateboarding (1) SNP (1) Social Communication Emotional Regulation Transitional Support (1) Software (4) Speaker Immersion (1) Speech-Language Therapy (2) Spirulina (1) Sports (1) SSRIs (1) Stem Cells (6) Stimulants (1) Studies (1) STX209 (2) Supplements (7) Surfing (2) Taekwondo (1) Tangible Time Management (1) TEACCH (5) Telehealth (1) Telemedicine (1) THC (4) The Secret (1) Therapeutic Horseback Riding (9) Therapy Dogs (1) THR (7) Time Timer (2) Timothy Syndrome (1) TMS (2) Toxic (1) Transcranial Magnetic Stimulation (2) Transgenic Mouse Model (1) Vanspar (1) VB (3) Verbal Behavior Approach (1) Verbal Behavior Model (3) Video Games (4) Video Modeling (1) Vitamin B6 [Pyridoxine] (1) Vitamins (6) Wii (1) Wrestling (1) Xbox Kinect (2) Yoga (7) Zinc (1)

Add This ...

Bookmark and Share